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KMID : 1130620080040010023
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Journal of Clinical Neurology
2008 Volume.4 No. 1 p.23 ~ p.28
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Association Between Parkinsonism and Participation in Agriculture in Korea
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Cho Jin-Whan
Jeong Du-Shin
Choi Yoon-Jae
Lee Jun-Young
Jeon Beom-Seok
Lee Hae-Sung
Hong Sae-Yong
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Abstract
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Background and Purpose: Environmental factors might influence the pathogenesis of Parkinson’s disease (PD)
or multiple-system atrophy (MSA), and previous examinations of pesticide exposure, well-water drinking, and
farming have produced inconclusive results. Because agriculture has been of considerable importance to Korean
society, and hence the risk of exposure to pesticides was high in Korea, this study investigated whether such
exposure is associated with elevated risks of developing PD and MSA.
Methods: Two hundred and thirty-five PD patients, 133 MSA patients, and 77 normal control subjects were
examined. Data concerning environmental factors were collected by face-to-face interviews using a structured
questionnaire. Odds ratios (ORs) were calculated by binary logistic regression.
Results: ORs for environmental risk factors for developing PD were 1.06 [95% confidence interval (CI) = 1.02-
1.10] for age and 2.37 (95% CI = 1.32-4.27) for rural well-water drinking for >10 years. Smoking >10 pack-years
(OR = 0.31; 95% CI = 0.11-0.64) was a preventable factor for developing PD in this study. However, no significant
risk factors were identified for MSA.
Conclusions: These results suggest that exposure to certain environmental risk factors plays a role in the
development of PD. However, the development of MSA appears to be independent of environmental risk factors in
Korean patients.
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KEYWORD
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Parkinson’s disease, Multiple-system atrophy, Pesticide, Well water, Smoking
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